Ho West District is one of the 25 districts in the Volta Region of Ghana. It was established by the Legislative Instrument (LI) 2083 of 2012.

It was curved out of Ho Municipality in January 2012 and inaugurated in June, 2013.The District derived its name from Ho West constituency. It is the highest political and administrative authority in the District. Its District capital is Dzolokpuita.

The population of the municipality according to 2010 population and housing census stands at 94,600 with 43,361 males and 49,239 females.