Pusiga District with its administrative capital Pusiga is one of the fifteen (15) administrative and political Districts in the Upper East Region of Ghana. It was carved out of the then Bawku Municipality in 2012 by Legislative Instrument, LI 2145.

The District is located approximately between latitude 110 111 and 100 401 north and longitude 00 18 1 W and 00 61 E in the north-eastern corner of the Region.

The District shares boundaries with Burkina-Faso to the north, Republic of Togo to the east, Bawku Municipality to the west and Garu District to the south. The District has total land size of about 50505 sq km.

The population of the District according to 2010 population and housing census stands at 57,677 with 27,516 males and 30,161 females.