The Agotime Ziope District is one of the 261 Metropolitan, Municipal and District Assemblies (MMDAs) in Ghana, and forms part of the 18 of Municipalities and Districts in the Volta Region.

Agotime-Ziope District was established by Legislative Instrument (LI 2080) in 2012. The former Adaklu-Anyigbe District was split into Agotime-Ziope and Adaklu Districts in June 2012. The capital of the District is Agotime Kpetoe located 22 kilometres east of the Volta Regional Capital Ho, along the Ho-Aflao Highway

The District shares boundaries with the Republic of Togo to the east; Akatsi North District and Central Tongu Districts to the south and the Adaklu District to the west and north. The District covers a total land area of about 330km.

The population of the District according to 2021 population and housing census stands at 39,553 with 18,791 males and 20,762 females.