The Assin South District is among the twenty two (22) Metropolitan, Municipalities and Districts of the Central Region of Ghana. 

Nsuaem-Kyekyewere is the Administrative capital of the District.

The District shares common boundaries with Twifo Hemang Lower Denkyira District on the west, Abura Asebu Kwamankese District on the south, Asikuma Odoben-Brakwa District and Ajumako Enyan-Esiam District respectively on the east and Assin Central Municipal to the Northern border.

The population of the district according to 2010 population and housing census stands at 104,244 with 50,936 male and 53,308 female.