The Lambussie-Karni District lies in the north-western corner of the Upper West Region of Ghana.
It is the ninth district to be created in the region.
The district was created from the Jirapa-Lambussie District Assembly by the legislative Instrument LI 1849 in 2007.
The district forms part of Eleven (11) Districts in the Upper West Region. and has its administrative capital at Lambussie.
The District shares boundaries to the south with Jirapa District Assembly, to the East with Sissala West District, to the West with the Nandom District and to the North with Burkina Faso. The District, therefore, serves as the National Gate way to Burkina Faso.
Other major towns in the District include Hamile, Samoa, Billaw, Piina and Karni.
The location of the District is strategic as its proximity to Burkina Faso could enhance cross border trade and other mutual relationships in terms of exchange of ideas for the development of the District.
The population of the municipality according to 2010 population and housing census stands at 51,654 with 24,952 males and 26,702 females.