Kpandai district was curved out of the East Gonja district on 29th of February 2008 by an Act of Parliament through a Legislative Instrument 1885. It has Kpandai as its administrative capital.

The district is located at the South-Eastern corner of the Northern Region of Ghana and lies between latitudes 8º N and 9.29º N and longitudes 0.29 º E and 1.26ºW.

It is bordered to the North by Nanumba South District, East Gonja Municipal to the west, Krachi West District to the south-west and Nkwanta North Municipal to the east. The district has a total land surface area of 1,132.9 Km Square.

The population of the district according to 2010 population and housing census stands at 108,816 with 54,997 males and 53,819 females.