The District is located in the South Eastern corner of the Upper East Region of the Republic of Ghana forms part of the fifteen (13) Districts in the Region.

It shares boundaries with, Bawku Municipal to the North, Binduri to the North West, Pusiga District to North East, East Mamprusi District to the South West, Bunkpurugu-Yunyoo District to South East, Bawku West District to the West and the Republic of Togo to the East.

It covers an area of 1,230 Km2. It lies on approximately latitude 10o 38lN and110N and longitude 0o 06l E and 00 23l E. The administative capital is Garu.

The population of the District according to 2010 population and housing census stands at 130,003 with 62,025 males and 67,978 females.