The Akatsi South District is one of the 260 Metropolitan, Municipal and District Assemblies (MMDAs) in Ghana, and forms part of the 18 of Municipalities and Districts in the Volta Region.

The District is located in the South-Eastern part of the Volta Region. It has a total land area of about 960.445 sq. km, the total land under cultivation is about 51,438.12 hectares. The District is located between latitude 6° S - 7° North 0° W - 1 ° W.  Akatsi is the administrative capital.

The District is bounded to the South by the Keta Municipal, to the east by the Ketu North Municipal, to the north by North Tongu Districts to the west, Agotime Ziope District and the Republic of Togo to complete the demarcation of the Akatsi District.

The population of the District according to 2010 population and housing census stands at 95,426 with 44,039 males and 51,387 females.