The District is located in the North Eastern part of Ghana. It lies approximately between Longitude 213w to 2:36w and Latitude 10:00N 11:00N. It shares Boundaries with the Jirapa Lambussie District to the West, Sissala East District to the East and Burkina Faso to the North and Wa East District to the South.

The district sharing border with Burkina Faso will facilitate cross border socio-economic activities. However, this has its own implications for health and crime wave. It covers a total Land area of 4,11289km, which is about 25% of the total Landmass of the Upper West Region.