The Sene District forms part of the Voltarian sandstone basin which is the most extensive physiographic region. The topography of the area is generally rolling and undulating. This is a potential for mechanized agricultural development. This is also an opportunity for the promotion and adoption of Intermediate Mode of Transport (IMT) in the district. The average height in the district is about 166 meters above sea level.
The district lies within the Sene-Obosom River Basins and the Volta Lake. Three major rivers drain the district. These are the Volta, the Pru and Sene Rivers. This has provided opportunities for the emergence of fishing as a major economic activity in the district.