The District is located in the South Eastern corner of the Upper East Region of the Republic of Ghana forms part of the Thirteen (13) Districts in the Region. It shares boundaries with, Bawku Municipal to the North, Binduri to the North West, Pusiga District to North East, East Mamprusi District to the South West, Bunkpurugu-Yunyoo District to South East, Bawku West District to the West and the Republic of Togo to the East. It covers an area of 1,230 Km2. It lies on approximately latitude 10o 38lN and110N and longitude 0o 06l E and 00 23l E. The administative capital is Garu.
Several interventions initiated by both government and some NGOs to mitigate the undesirable enrolment gap between boys and girls in the primary level of education within the Garu-Tempane district has tended to yield good results.
The Garu-Tempane District Assembly has estimated to as a matter of urgency prosecute plans of expanding potable water system to several areas within its enclave to enhance the living conditions of residents in the district.