Nkwanta South District is one of the twenty five (25) Municipalities and Districts in the Volta Region of Ghana. The District is located in the northern - most part of the Region. It lies between latitudes 7 30° and 8 45° North and longitude 0 10° and 0 45° East. The district is bounded to the north by the Nkwanta North District, to the south by the Kadjebi District, to the East by the Republic of Togo and to the West by Krachi East District. Nkwanta South District was carved out of Kete Krachi District in 1989. The Administrative Capital of the District is Nkwanta .
President John Dramani Mahama has stated that everything would be done to apprehend the killers of the District Chief Executive (DCE) of Nkwanta South, Mr Peter Kojo Kenyenso, who was shot dead by unknown assailants in the evening of November 3, 2014 just after he had alighted from his car.