The Sissala East District is located in the north-western part of Ghana in the Upper West Region. The district capital is Tumu. The ditrict is strategically positioned as it shares a 300 kilometre border with Burkina Faso.
To the east, it shares boundaries with Kassena Nankana and Builsa district, both of the Upper East Region while its extreme southeastern portion shares a boundary with West Mamprusi District of the Northern Region. Its neighbours in the Upper West Region are Wa and Nadowli districts to the south and Jirapa district to the west.
The Sissala East District is located in the north-western part of Ghana in the Upper West Region. The district capital is Tumu. The ditrict is strategically positioned as it shares a 300 kilometre border with Burkina Faso.